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Representative Research Papers

  1. ASD/OCD-linked Protocadherin-10 regulates synapse, but not axon, development in the amygdala and contributes to fear- and anxiety-related behaviors. Hoshina N, Johnson-Venkatesh EM, Rally VR, Sant J, Hoshina M, Seiglie MP, Umemori H. J. Neurosci. 2022.

  2. Female-specific synaptic dysfunction and cognitive impairment in a mouse model of PCDH19 disorder. Hoshina N, Johnson-Venkatesh EM, Hoshina M, Umemori H. Science. 2021.  Full text;   Reprint
  3. An activity-dependent determinant of synapse elimination in the mammalian brain. Yasuda M, Nagappan-Chettiar S, Johnson-Venkatesh EM, Umemori H. Neuron. 2021.   Full text
  4. Tyrosine phosphorylation of the transmembrane protein SIRPα: sensing synaptic activity and regulating ectodomain cleavage for synapse maturation. Nagappan-Chettiar S, Johnson-Venkatesh EM, Umemori H. J Biol. Chem. 2018
  5. Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain. Terauchi A, Johnson-Venkatesh EM, Bullock B, Lehtinen MK, Umemori H. eLife. 2016
  6. Deletion of fibroblast growth factor 22 (FGF22) causes a depression-like phenotype in adult mice. Williams AJ, Yee P, Smith MC, Murphy GG, Umemori H. Behav Brain Res. 2016
  7. Excitability governs neural development in a hippocampal region-specific manner. Johnson-Venkatesh EM, Khan MN, Murphy GG, Sutton MA, Umemori H. Development. 2015
  8. Distinct sets of FGF receptors sculpt excitatory and inhibitory synaptogenesis. Dabrowski A, Terauchi A, Strong C, Umemori H. Development. 2015

  9. Selective synaptic targeting of the excitatory and inhibitory presynaptic organizers FGF22 and FGF7. Terauchi A, Timmons KM, Kikuma K, Pechmann Y, Kneussel M, Umemori H. J Cell Sci. 2015

  10. Synapse maturation by activity-dependent ectodomain shedding of SIRPα. Toth AB, Terauchi A, Zhang LY, Johnson-Venkatesh EM, Larsen DJ, Sutton MA, Umemori H. Nat Neurosci. 2013

  11. Multiple forms of activity-dependent competition refine hippocampal circuits in vivo. Yasuda M, Johnson-Venkatesh EM, Zhang H, Parent JM, Sutton MA, Umemori H. Neuron. 2011

  12. Distinct FGFs promote differentiation of excitatory and inhibitory cell.cover.lrg copysynapses. Terauchi A, Johnson-Venkatesh EM, Toth AB, Javed D, Sutton MA, Umemori H. Nature. 2010

  13. Distinct target-derived signals organize formation, maturation and maintenance of motor nerve terminals. Fox MA, Sanes JR, Borza DB, Eswarkumar VP, Fassler R, Hudson B, John SWM, Ninomiya Y, Pedchenko V, Pfaff SL, Rheault M, Sado Y, Segal Y, Werle MJ, & Umemori H. Cell. 2007

  14. FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain. Umemori H, Linhoff MW, Ornitz DM, & Sanes JR. Cell. 2004 [Cover Article]


  1. Activity-dependent proteolytic cleavage of cell adhesion molecules regulates excitatory synaptic development and function. Nagappan-Chettiar S, Johnson-Venkatesh EM, Umemori H. Neurosci Res. 2017
  2. The best-laid plans go oft awry: synaptogenic growth factor signaling in neuropsychiatric disease. Williams AJ, Umemori H. Front Synaptic Neurosci. 2014

  3. Specific sets of intrinsic and extrinsic factors drive excitatory and inhibitory circuit formation. Terauchi A, Umemori H. Neuroscientist. 2012

  4. Orchestrating the synaptic network by tyrosine phosphorylation signaling. Dabrowski A, Umemori H. J Biochem. 2011

  5. Secreted factors as synaptic organizers. Johnson-Venkatesh EM & Umemori H. Eur. J. Neurosci. 2010

  6. Seeking long term relationship: Axon and target communicate to organize synaptic differentiation. Fox MA & Umemori H. J. Neurochem. 2006